• yuxiaochun@westlake.edu.cn
  • Hangzhou, Zhejiang, China
  • Join Research
Publication
  • 2020-2024
  • 2015-2019
  • 2010-2014
  • 2000-2009
* = Corresponding Author.
Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM.
Nature Methods (2024)
Zijing Ouyang, Qian Wang, Xiaoyu Li, Qiuyang Dai, Muyuan Tang, Lin Shao, Wen Gou, Zijing Yu, Yanqin Chen, Bei Zheng, Linlin Chen, Conghui Ping, Xiuli Bi, Bin Xiao, Xiaochun Yu, Changliang Liu, Liangyi Chen*, Junchao Fan*, Xiaoshuai Huang*, Yongdeng Zhang*
(Dec, 2024)
DOI: 10.1038/s41592-024-02515-z
PubMed
The complete telomere-to-telomere sequence of a mouse genome.
Science (2024), Vol. 386, No. 6726, PP. 1141-1146
Junli Liu, Qilin Li, Yixuan Hu, Yi Yu, Kai Zheng, Dengfeng Li, Lexin Qin, Xiaochun Yu*
(Dec, 2024)
DOI: 10.1126/science.adq8191
PubMed
RNA 2'-O-methylation promotes persistent R-loop formation and AID-mediated IgH class switch recombination.
BMC Biology (2024), Vol. 22, No. 1, PP. 151
Muzaffer Ahmad Kassab, Yibin Chen, Xin Wang, Bo He, Eric J. Brown, Xiaochun Yu*
(Jul, 2024)
DOI: 10.1186/s12915-024-01947-5
PubMed
The role of rRNA in maintaining genome stability.
DNA Repair (2024), Vol. 139, PP. 103692
Peng Li, Xiaochun Yu*
(Jul, 2024)
DOI: 10.1016/j.dnarep.2024.103692
PubMed
DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repair.
Nucleic Acids Research (2024), Vol. 52, No. 11, PP. 6360-6375
Peng Li, Xiaochen Gai, Qilin Li, Qianqian Yang, Xiaochun Yu*
(Jun, 2024)
DOI: 10.1093/nar/gkae316
PubMed
Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks.
Journal of Biological Chemistry (2024), Vol. 300, No. 3, PP. 107115
Linlin Chen, Xiaochen Gai, Xiaochun Yu*
(March, 2024)
DOI: 10.1016/j.jbc.2024.107115
PubMed
The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination.
Cell Discovery (2023), Vol. 9, No. 1, PP. 99
Duo Wu, Huang Huang, Tenglong Chen, Xiaochen Gai, Qilin Li, Chunhui Wang, Jia Yao, Yu Liu, Shang Cai, Xiaochun Yu*
(Oct, 2023)
DOI: 10.1038/s41421-023-00590-8
PubMed
Pre-rRNA Facilitates TopBP1-Mediated DNA Double-Strand Break Response.
Advanced Science (2023), Vol. 10, No. 28, PP. 2206931
Di Xin, Xiaochen Gai, Yidi Ma, Zexing Li, Qilin Li, Xiaochun Yu*
(Aug, 2023)
DOI: 10.1002/advs.202206931
PubMed
ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis.
Journal of Molecular Cell Biology (2023), Vol. 15, No. 7, PP. mjad043
Xueyao Ma, Mengyuan Li, Yi Liu, Xuefang Zhang, Xiaoyun Yang, Yun Wang, Yipeng Li, Jiayue Wang, Xiuhua Liu, Zhenzhen Yan*, Xiaochun Yu*, Chen Wu* (Jun, 2023)
DOI: 10.1093/jmcb/mjad043
PubMed
Ribosomal RNA regulates chromosome clustering during mitosis.
Cell Discovery (2022), Vol. 8, No. 1, PP. 51
Kai Ma, Man Luo, Guanglei Xie, Xi Wang, Qilin Li, Lei Gao, Hongtao Yu, Xiaochun Yu*
(May, 2022)
DOI: 10.1038/s41421-022-00400-7
PubMed
Functional defects of cancer-associated MDC1 mutations in DNA damage repair.
DNA Repair (Amst) (2022), Vol. 114, PP. 103330
Rong Xie, Zhenzhen Yan, Ju Jing, Yukun Wang, Jiajia Zhang, Yiping Li, Xiuhua Liu,
Xiaochun Yu*, Chen Wu* (Jun, 2022)
DOI: 10.1016/j.dnarep.2022.103330
PubMed
The impact of TOPBP1 mutations in human cancers on the DNA damage response.
Genome Instability and Disease (2022), Vol. 3, PP. 144-62
Zhezhen Yan, Xiuling Ge, Jiaxu Wang, Feng Xu, Mengyao Li, Xiuhua Liu*, Xiaochun Yu*,
Chen Wu* (Apr, 2022)
DOI: 10.1007/s42764-022-00072-3
PubMed
Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis.
Cell Discovery (2022), Vol. 8, No. 1, PP. 3
Qian Chen*, Kai Ma, Xiuhua Liu, Shih-Hsun Chen, Peng Li, Yonghao Yu, Anthony K.L. Leung,
Xiaochun Yu* (Jan, 2022)
DOI: 10.1038/s41421-021-00355-1
PubMed
Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response.
Cell Research (2022), Vol. 32, No. 3, PP. 254-68
Xiaochen Gai, Di Xin, Duo Wu, Xin Wang, Linlin Chen, Yiqing Wang, Kai Ma, Qilin Li, Peng Li,
Xiaochun Yu* (Mar, 2022)
DOI: 10.1038/s41422-021-00597-4
PubMed
OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.
Cell Death and Disease (2021), Vol. 12, No. 7, PP. 622
Yaqi Cui, Rong Xie, Xuefang Zhang, Yi Liu, Yixuan Hu, Yuan Li, Xiuhua Liu*, Xiaochun Yu*,
Chen Wu* (Jun, 2021)
DOI: 10.1038/s41419-021-03910-6
PubMed
ATR/ATM-mediated phosphorylation of BRCA1 T1394 promotes homologous recombinational repair and G2-M checkpoint maintenance.
Cancer Research (2021), Vol. 81, No. 18, PP. 4676-84
Tzeh K. Foo, Gabriele Vincelli, Eric Huselid, Joonyoung Her, Haiyan Zheng, Srilatha Simhadri,
Meiling Wang, Yanying Huo, Tao Li, Xiaochun Yu, Hong Li, Weixing Zhao, Samuel F. Bunting,
Bing Xia* (Sep, 2021)
DOI: 10.1158/0008-5472.CAN-20-2723
PubMed
ADP-ribosyltransferases, an update on function and nomenclature.
The FEBS Journal (2021), Vol. 289, No. 23, PP. 7399-7410
Bernhard Lüscher*, Ivan Ahel, Matthias Altmeyer, Alan Ashworth, Peter Bai, Paul Chang,
Michael Cohen, Daniela Corda, Françoise Dantzer, Matthew D. Daugherty, Ted M. Dawson,
Valina L. Dawson, Sebastian Deindl, Anthony R. Fehr, Karla L. H. Feijs, Dmitri V. Filippov,
Jean-Philippe Gagné, Giovanna Grimaldi, Sebastian Guettler, Nicolas C. Hoch,
Michael O. Hottiger, Patricia Korn, W. Lee Kraus, Andreas Ladurner, Lari Lehtiö,
Anthony K. L. Leung, Christopher J. Lord, Aswin Mangerich, Ivan Matic, Jason Matthews,
George-Lucian Moldovan, Joel Moss, Gioacchino Natoli, Michael L. Nielsen, Mario Niepel,
Friedrich Nolte, John Pascal, Bryce M. Paschal, Krzysztof Pawłowski, Guy G. Poirier,
Susan Smith, Gyula Timinszky, Zhao-Qi Wang, José Yélamos, Xiaochun Yu, Roko Zaja,
Mathias Ziegler (Jul, 2021)
DOI: 10.1111/febs.16142
PubMed
ATR prevents Ca2+ overload-induced necrotic cell death through phosphorylation-mediated inactivation of PARP1 without DNA damage signaling.
FASEB Journal (2021), Vol. 35, No. 5, PP. e21373
Zhengke Li, Hui Wang-Heaton, Brian M Cartwright, Yetunde Makinwa,Benjamin A Hilton,
Phillip R Musich, Nikolozi Shkriabai, Mamuka Kvaratskhelia, Shengheng Guan, Qian Chen,
Xiaochun Yu, Yue Zou* (May, 2021)
DOI: 10.1096/fj.202001636RRR
PubMed
Cancer-associated 53BP1 mutations induce DNA damage repair defects.
Cancer Letters (2021), Vol. 501, PP. 43-54
Jiajia Zhang, Zhenzhen Yan, Yukun Wang, Yaguang Wang, Xin Guo, Ju JIng, Xiangnan Dong,
Shasha Dong, Xiuhua Liu*, Xiaochun Yu*, Chen Wu* (Mar, 2021)
DOI: 10.1016/j.canlet.2020.12.033
PubMed
ADP-ribosylhydrolases: from DNA damage repair to COVID-19.
Journal of Zhejiang University Science B (2021), Vol. 22, No. 1, PP. 21-30
Lily Yu, Xiuhua Liu, Xiaochun Yu* (Jan, 2021)
DOI: 10.1631/jzus.B2000319
PubMed
ADP-ribosylation of histone variant H2AX promotes base excision repair.
The EMBO Journal (2021), Vol. 40, No. 2, PP. e104542
Qian Chen*, Chunjing Bian, Xin Wang, Xiuhua Liu, Muzaffer Ahmad Kassab, Yonghao Yu,
Xiaochun Yu* (Jan, 2021)
DOI: 10.15252/embj.2020104542
PubMed
AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair.
Journal of Biological Chemistry (2020), Vol. 295, No. 40, PP. 13848-9
Xiuhua Liu‡, Rong Xie‡, Lily L. Yu‡, Shih-Hsun Chen‡, Xiaoyun Yang, Anup K. Singh,
Hongzhi Li, Chen Wu, Xiaochun Yu* (Oct, 2020)
DOI: 10.1074/jbc.RA120.012801
PubMed
Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation.
DNA Repair (Amst) (2020), Vol. 94, PP. 102899
Xiaoyun Yang, Yinliang Ma, Yimiao Li, Yating Dong, Lily L. Yu, Hong Wang, Lulin Guo,
Chen Wu*, Xiaochun Yu*, Xiuhua Liu* (Oct, 2020)
DOI: 10.1016/j.dnarep.2020.102899
PubMed
Tissue-specific-carcinogens as soil to seed BRCA1/2-mutant hereditary cancers.
Trends in Cancer (2020), Vol. 6, No. 7, PP. 559-68
by Anup Kumar Singh, Xiaochun Yu* (Jul, 2020)
DOI: 10.1016/j.trecan.2020.03.004
PubMed
Selective targeting of TET catalytic domain promotes somatic cell reprogramming.
Proceedings of the National Academy of Sciences (2020), Vol. 117, No. 7, PP. 3621-6
Anup Kumar Singh, Bo Zhao, Xiuhua Liu, Xin Wang, Hongzhi Li, Hanjun Qin, Xiwei Wu,
Yuelong Ma, David Horne, Xiaochun Yu* (Feb, 2020)
DOI: 10.1073/pnas.1910702117
PubMed
Targeting dePARylation for cancer therapy.
Cell and Bioscience (2020), Vol. 10, No. 7
Muzaffer Ahmad Kassab, Lily L Yu, Xiaochun Yu* (Jan, 2020)
DOI: 10.1186/s13578-020-0375-y
PubMed
Poly(ADP-ribosyl)ation mediates early phase histone eviction at DNA lesions.
Nucleic Acids Research (2020), Vol. 48, No. 6, PP. 3001-13
Guang Yang, Yibin Chen, Jiaxue Wu, Shih-Hsun Chen, Xiuhua Liu, Anup Kumar Singh,
Xiaochun Yu* (Apr, 2020)
DOI: 10.1093/nar/gkaa022
PubMed
Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.
Oncogene (2020), Vol. 39, No. 6, PP. 1246-59
Shafat Ali, Yilan Zhang, Mian Zhou, Hongzhi Li, Weiwei Jin, Li Zheng, Xiaochun Yu,
Jeremy M Stark, Jeffrey N Weitzel, Binghui Shen* (Feb, 2020)
DOI: 10.1038/s41388-019-1061-6
PubMed
Silencing of CHFR sensitizes gastric carcinoma to PARP inhibitor treatment.
Translational Oncology (2020), Vol. 13, No. 1, PP. 113-21
Yuan Li‡, Yanyan Shi‡, Xiumin Wang‡, Xiaochun Yu*, Chen Wu*, Shigang Ding*
(Jan, 2020)
DOI: 10.1016/j.tranon.2019.10.004
PubMed
The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing.
Journal of Molecular Cell Biology (2020), Vol. 12, No. 2, PP. 113-24
Chen Wu‡, Yaqi Cui‡, Xiuhua Liu, Feng Zhang, Lin-Yu Lu, Xiaochun Yu* (Feb, 2020)
DOI: 10.1093/jmcb/mjz045
PubMed
Poly-ADP ribosylation in DNA damage response and cancer therapy.
Mutation Research (2019), Vol. 780, PP. 82-91
Wei-Hsien Hou, Shih-Hsun Chen, Xiaochun Yu* (Apr, 2019)
DOI: 10.1016/j.mrrev.2017.09.004
PubMed
Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.
Science Advances (2019), Vol. 5, No. 4, PP. eaav4340
Shih-Hsun Chen, Xiaochun Yu* (Apr, 2019)
DOI: 10.1126/sciadv.aav4340
PubMed
The role of dePARylation in DNA damage repair and cancer suppression.
DNA repair (2019), Vol. 76, PP. 20-29
Muzaffer Ahmad Kassab, Xiaochun Yu* (Apr, 2019)
DOI: 10.1016/j.dnarep.2019.02.002
PubMed
NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.
Nature Communications (2019), Vol. 10, No. 1, PP. 693
Chunjing Bian‡, Chao Zhang‡, Tao Luo‡, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong, Xiaochun Yu* (Feb, 2019)
DOI: 10.1038/s41467-019-08530-5
PubMed
Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation.
Nucleic Acids Research (2019), Vol. 47, No. 3, PP. 1321-1334
Shih-Hsun Chen, Xiaochun Yu* (Feb, 2019)
DOI: 10.1093/nar/gky1202
PubMed
SIRT1 activation disrupts maintenance of myelodysplastic syndrome stem and progenitor cells by restoring TET2 function.
Cell Stem Cell (2018), Vol. 23, No. 3, PP. 355-69
Jie Sun, Xin He, Yinghui Zhu, Zonghui Ding, Haojie Dong, Yimei Feng, Juan Du, Hanying Wang,
Xiwei Wu, Lei Zhang, Xiaochun Yu, Allen Lin, Tinisha McDonald, Dandan Zhao, Herman Wu,
Wei-Kai Hua, Bin Zhang, Lifeng Feng, Kaoru Tohyama, Ravi Bhatia, Philipp Oberdoerffer,
Yang Jo Chung, Peter D Aplan, Jacqueline Boultwood, Andrea Pellagatti, Samer Khaled,
Marcin Kortylewski, Flavia Pichiorri, Ya-Huei Kuo, Nadia Carlesso, Guido Marcucci,
Hongchuan Jin*, Ling Li* (Sep, 2018)
DOI: 10.1016/j.stem.2018.07.018
PubMed
PARP2 mediates branched poly-ADP-ribosylation in response to DNA damage.
Nature Communications (2018), Vol. 9, No. 1, PP. 3233
Qian Chen, Muzaffer Ahmad Kassab, Françoise Dantzer, Xiaochun Yu* (Aug, 2018)
DOI: 10.1038/s41467-018-05588-5
PubMed
LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway.
Oncogenesis (2018), Vol. 7, No. 8, PP. 57
Xiangfei Wang, Xiumin Wang, Yang Liu, Yating Dong, Yanan Wang, Muzaffer Ahmad Kassab,
Wufang Fan*, Xiaochun Yu*, Chen Wu* (Aug, 2018)
DOI: 10.1038/s41389-018-0071-5
PubMed
Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation.
The Journal of Biological Chemistry (2018), Vol. 293, No. 37, PP. 14470-80
Mengxi Wang‡, Zenglin Yuan‡, Rong Xie‡, Yinliang Ma, Xiuhua Liu*, Xiaochun Yu*
(Sep, 2018)
DOI: 10.1074/jbc.RA118.004284
PubMed
Structure basis for the inhibition of the methyl-lysine binding function of 53BP1 by NUDT16L1/TIRR.
Nature Communications (2018), Vol. 9, No. 1, PP. 2689
Jiaxu Wang‡, Zenglin Yuan‡, Yaqi Cui‡, Rong Xie, Guang Yang, Muzaffer A Kassab,
Mengxi Wang, Yinliang Ma, Chen Wu, Xiaochun Yu*, Xiuhua Liu* (Jul, 2018)
DOI: 10.1038/s41467-018-05174-9
PubMed
GALNT14 involves the regulation of multidrug resistance in breast cancer.
Translational Oncology (2018), Vol. 11, No. 3, PP. 786-93
Jinshuai Shan, Yang Liu, Yukun Wang, Yimiao Li, Xiaochun Yu*, Chen Wu* (Jun, 2018)
DOI: 10.1016/j.tranon.2018.04.003
PubMed
Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors.
Nucleic Acids Research (2018), Vol. 46, No. 7, PP. 3446-57
Guang Yang, Chao Liu, Shih-Hsun Chen, Muzaffer A Kassab, J Damon Hoff, Nils G Walter,
Xiaochun Yu* (Apr, 2018)
DOI: 10.1093/nar/gky088
PubMed
EFEMP2 Mediates GALNT14-Dependent Breast Cancer Cell Invasion.
Translational Oncology (2018), Vol. 11, No. 2, PP. 346-52
Tao Zuo‡, Jinshuai Shan‡, Yang Liu, Rong Xie, Xiaochun Yu*, Chen Wu* (Apr, 2018)
DOI: 10.1016/j.tranon.2018.01.021
PubMed
The role of poly ADP-ribosylation in the first wave of DNA damage response.
Nucleic Acids Research (2017), Vol. 45, No. 14, PP. 8129-41
Chao Liu, Aditi Vyas, Muzaffer A. Kassab, Anup K. Singh, Xiaochun Yu* (Aug, 2017)
DOI: 10.1093/nar/gkx565
PubMed
Targeting reactive nitrogen species suppresses hereditary pancreatic cancer
Proceedings of the National Academy of Sciences (2017), Vol. 114, No. 27, PP. 7106-11
Mo Li, Qian Chen, Teng Ma, Xiaochun Yu* (Jul, 2017)
DOI: 10.1073/pnas.1702156114
PubMed
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.
Epigenetics (2017), Vol. 12, No. 7, PP. 551-60
Yidan Liu, Bin Zhang, Xiaoyu Meng, Matthew J Korn, Jack M Parent, Lin-Yu Lu*,
Xiaochun Yu* (Jul, 2017)
DOI: 10.1080/15592294.2017.1314423
PubMed
CTCF participates in DNA damage response via poly(ADP-ribosyl)ation.
Science Reports (2017), Vol. 7, PP. 43530
Deqiang Han‡, Qian Chen‡, Jiazhong Shi‡, Feng Zhang, Xiaochun Yu* (Mar, 2017)
DOI: 10.1038/srep43530
PubMed
Chemopreventive effects of ROS targeting in a murine model of BRCA1-deficient breast cancer.
Cancer Research (2017), Vol. 77, No. 2, PP. 448-58
Mo Li, Qian Chen, Xiaochun Yu* (Jan, 2017)
DOI: 10.1158/0008-5472.CAN-16-2350
PubMed
OGT restrains the expansion of DNA damage signaling.
Nucleic Acids Research (2016), Vol. 44, No. 19, PP. 9266-78
Qiang Chen, Xiaochun Yu* (Nov, 2016)
DOI: 10.1093/nar/gkw663
PubMed
A special Issue on DNA damage response and genomic instability.
Acta Biochimica et Biophysica Sinica (Shanghai) (2016), Vol. 48, No. 7, PP. 593
Xiaochun Yu* (Jul, 2016)
DOI: doi: 10.1093/abbs/gmw051
PubMed
Functions of PARylation in DNA damage repair pathway.
Genomics Proteomics Bioinformatics (2016), Vol. 14, No. 3, PP. 131-9
Huiting Wei, Xiaochun Yu* (Jun, 2016)
DOI: 10.1016/j.gpb.2016.05.001
PubMed
Zinc Finger Protein 618 regulates the function of UHRF2 as a specific 5-hydroxymenthylcytosine reader.
Journal of Biological Chemistry. (2016), Vol. 291, No. 26, PP. 13679-88
Yidan Liu, Bin Zhang, Henry Kuang, Gautam Korakavi, Lin-Yu Lu*, Xiaochun Yu*
(Jun, 2016)
DOI: 10.1074/jbc.M116.717314
PubMed
Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer.
JAMA Oncology (2016), Vol. 2, No. 4, PP. 471-80
Joseph R Evans, Shuang G Zhao, S Laura Chang, Scott A Tomlins, Nicholas Erho,
Andrea Sboner, Matthew J Schiewer, Daniel E Spratt, Vishal Kothari, Eric A Klein,
Robert B Den, Adam P Dicker, R Jeffrey Karnes, Xiaochun Yu, Paul L Nguyen,
Mark A Rubin, Johann de Bono, Karen E Knudsen, Elai Davicioni, Felix Y Feng*
(Apr, 2016)
DOI: 10.1001/jamaoncol.2015.4955
PubMed
CHFR is important for the survival of male premeiotic germ cells.
Cell Cycle (2015), Vol. 14, No. 21, PP. 3454-60
Lin-Yu Lu, Xiaochun Yu* (Nov, 2015)
DOI: 10.1080/15384101.2015.1093701
PubMed
Poly(ADP-ribosyl)ation mediates the BRCA2-dependent early DNA damage response.
Cell Reports (2015), Vol. 13, No. 4, PP. 678-89
Feng Zhang, Jiazhong Shi, Chunjing Bian, Xiaochun Yu* (Oct, 2015)
DOI: 10.1016/j.celrep.2015.09.040
PubMed
The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response.
Nucleic Acids Research (2015), Vol. 43, No. 22, PP. 10782-94
Feng Zhang‡, Jiazhong Shi‡, Shih-Hsun Chen, Chunjing Bian, Xiaochun Yu* (Dec, 2015)
DOI: 10.1093/nar/gkv939
PubMed
ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.
The Journal of Biological Chemistry (2015), Vol. 290, No. 45, PP. 27146-57
Huibin Yang‡, Phillip L Palmbos‡, Lidong Wang, Evelyn H Kim, Gina M Ney,
Chao Liu, Jayendra Prasad, David E Misek, Xiaochun Yu, Mats Ljungman,
Diane M Simeone* (Nov, 2015)
DOI: doi: 10.1074/jbc.M115.665489
PubMed
RNF8 deficiency results in neurodegeneration in mice.
Neurobiology of Aging (2015), Vol. 36, No. 10, PP. 2850-60
Siwei Ouyang‡, Yanfeng Song‡, Yingxia Tian‡, Yibin Chen, Xiaochun Yu,
Degui Wang* (Oct, 2015)
DOI: 10.1016/j.neurobiolaging.2015.07.010
PubMed
ADP-ribosyltransferases and Poly ADP-ribosylation.
Current Protein and Peptide Scicnce (2015), Vol. 16, No. 6, PP. 491-501
Chao Liu, Xiaochun Yu* (May, 2015)
DOI: 10.2174/1389203716666150504122435
PubMed
Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.
Molecular Cell (2015), Vol. 58, No. 1, PP. 172-85
Wenxia Jiang‡, Jennifer L Crowe‡, Xiangyu Liu‡, Satoshi Nakajima, Yunyue Wang,
Chen Li, Brian J Lee, Richard L Dubois, Chao Liu, Xiaochun Yu, Li Lan, Shan Zha*
(Apr, 2015)
DOI: 10.1016/j.molcel.2015.02.024
PubMed
ZNF644 and WIZ regulate the G9a/GLP complex for gene repression.
eLife (2015), Vol. 4, PP. e05606
Chunjing Bian‡, Qiang Chen‡, Xiaochun Yu* (Mar, 2015)
DOI: 10.7554/eLife.05606
PubMed
Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage.
BMB Reports (2015), Vol. 48, No. 6, PP. 354-9
Chao Zhang, Tao Luo, Shijun Cui, Yongquan Gu, Chunjing Bian, Yibin Chen, Xiaochun Yu*,
Zhonggao Wang* (Jun, 2015)
DOI: 10.5483/BMBRep.2015.48.6.012
PubMed
Double-strand break repair on sex chromosomes: challenges during male meiotic prophase.
Cell Cycle (2015), Vol. 14, No. 4, PP. 516-25
Lin-Yu Lu*, Xiaochun Yu* (Jan, 2015)
DOI: 10.1080/15384101.2014.998070
PubMed
Topoisomerase II regulates the maintenance of DNA Methylation.
The Journal of Biological Chemistry (2015), Vol. 290, No. 2, PP. 851-60
Lin-Yu Lu*, Henry Kuang, Gautam Korakavi, Xiaochun Yu* (Jan, 2015)
DOI: 10.1074/jbc.M114.611509
PubMed
The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy.
Oncogene (2015), Vol. 34, No. 26, PP. 3349-56
Mo Li, Xiaochun Yu* (Jun, 2015)
DOI: 10.1038/onc.2014.295
PubMed
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis.
Cell Cycle (2014), Vol. 13, No. 18, PP. 2944-51
Mo LI, Chunjing Bian, Xiaochun Yu* (Oct, 2014)
DOI: 10.4161/15384101.2014.947197
PubMed
Elevated DNA damage response in pancreatic cancer.
Histochemistry and Cell Biology (2014), Vol. 142, No. 6, PP. 713-20
Michael Osterman‡, Deion Kathawa‡, Diangang Liu‡, Huan Guo, Chao Zhang, Mo Li*, Xiaochun Yu*, Fei Li* (Dec, 2014)
DOI: 10.1007/s00418-014-1245-7
PubMed
The OB-fold motif is a polyADP-ribose-binding domain that mediates DNA damage response.
Proceedings of the National Academy of Sciences (2014), Vol. 111, No. 20, PP. 7278-83
Feng Zhang, Yibin Chen, Mo Li, Xiaochun Yu* (May, 2014)
DOI: 10.1073/pnas.1318367111
PubMed
ATDC/TRIM29 phosphorylation by ATM/MAPKAP kinase 2 mediates radioresistance in pancreatic cancer cells.
Cancer Research. (2014), Vol. 74, No. 6, PP. 1778-88
Lidong Wang, Huibin Yang, Phillip L Palmbos, Gina Ney, Taylor Ann Detzler, Dawn Coleman,
Jacob Leflein, Mary Davis, Min Zhang, Wenhua Tang, J Kevin Hicks, Corey M Helchowski,
Jayendra Prasad, Theodore S Lawrence, Liang Xu, Xiaochun Yu, Christine E Canman,
Mats Ljungman, Diane M Simeone* (Mar, 2014)
DOI: 10.1158/0008-5472.CAN-13-2289
PubMed
H2A.B facilitates transcription elongation at methylated CpG loci.
Genome Research (2014), Vol. 24, No. 4, PP. 570-9
Yibin Chen, Qiang Chen, Richard C McEachin, James D Cavalcoli, Xiaochun Yu*
(Apr, 2014)
DOI: 10.1101/gr.156877.113
PubMed
Crosstalk between TGF-β/Smad3 and BMP/BMPR2 signaling pathway via miR-17-92 cluster in carotid artery restenosis.
Molecular and Cellular Biology (2014), Vol. 389, No. 1-2, PP. 169-76
Tao Luo, Shijun Cui, Chunjing Bian, Xiaochun Yu* (Apr, 2014)
DOI: 10.1007/s11010-013-1938-6
PubMed
PGC7 suppresses TET3 for protecting DNA methylation.
Nucleic Acids Research (2014), Vol. 42, No. 5, PP. 2893-905
Chunjing Bian, Xiaochun Yu* (Mar, 2014)
DOI: 10.1093/nar/gkt1261
PubMed
DNA double-strand break repair is activated in carotid artery restenosis.
Cell Molecular Biology (Noisy-le-grand) (2013), Suppl. 59, PP. 1869-75
Tao Luo, Shijun Cui, Chunjing Bian, Xiaochun Yu* (Oct, 2013)
DOI: 10.1170/222
PubMed
A core hSSB1-INTS complex participates in DNA damage response.
Journal of Cell Science (2013), Vol. 126, No. 21, PP. 4850-55
Feng Zhang, Teng Ma, Xiaochun Yu* (Nov, 2013)
DOI: 10.1242/jcs.132514
PubMed
The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response.
Genes & Development (2013), Vol. 27, No. 16, PP. 1752-68
Mo Li, Lin-Yu Lu, Chao-Yie Yang, Shaomeng Wang, Xiaochun Yu* (Aug, 2013)
DOI: 10.1101/gad.226357.113
PubMed
Regulation of the DNA damage response on male meiotic sex chromosomes.
Nature Communications (2013), Vol. 4, PP. 2105
Lin-Yu Lu, Yi Xiong, Henry Kuang, Gautam Korakavi, Xiaochun Yu* (Jun, 2013)
DOI: 10.1038/ncomms3105
PubMed
Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation.
Cancer Cell (2013), Vol. 23, No. 5, PP. 693-704
Mo Li, Xiaochun Yu* (May, 2013)
DOI: 10.1016/j.ccr.2013.03.025
PubMed
RNF168 forms a functional Complex with RAD6 during DNA damage response.
Journal of Cell Science (2013), Vol. 126, No. 9, PP. 2042-51
Chao Liu‡, Degui Wang‡, Jiaxue Wu, Jennifer Keller, Teng Ma, Xiaochun Yu* (May, 2013)
DOI: 10.1242/jcs.122945
PubMed
RNF111-dependent neddylation activates DNA damage-induced ubiquitination.
Molecular Cell (2013), Vol. 49, No. 5, PP. 897-907
Teng Ma, Yibin Chen, Feng Zhang, Chao-Yie Yang, Shaomeng Wang, Xiaochun Yu*
(Mar, 2013)
DOI: 10.1016/j.molcel.2013.01.006
PubMed
FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1.
Cancer Research (2013), Vol. 73, No. 7, PP. 2170-80
Weiquan Li, Hiroto Katoh, Lizhong Wang, Xiaochun Yu, Zhanwen Du, Xiaoli Yan,
Pan Zheng*, Yang Liu* (Apr, 2013)
DOI: 10.1158/0008-5472.CAN-12-2481
PubMed
CHFR is important for the first wave of ubiquitination at DNA damage sites.
Nucleic Acids Research (2013), Vol. 41, No. 3, PP. 1698-710
Chao Liu‡, Jiaxue Wu‡, Sharad C Paudyal, Zhongsheng You, Xiaochun Yu* (Feb, 2013)
DOI: 10.1093/nar/gks1278
PubMed
TET2 promotes histone O-GlcNacylation during gene transcription.
Nature (2013), Vol. 493, No. 7433, PP. 561-4
Qiang Chen, Yibin Chen, Chunjing Bian, Ryoji Fujiki, Xiaochun Yu* (Jan, 2013)
DOI: 10.1038/nature11742
PubMed
Loss of BRCA1-A complex function in RAP80 null ovarian tumor cells.
PLos One (2012), Vol. 7, No. 7, PP. e40406
Chunjing Bian‡, Rong Wu‡, Kathleen Cho, Xiaochun Yu (Jul, 2012)
DOI: 10.1371/journal.pone.0040406
PubMed
RNF20 and USP44 regulate stem cell differentiation by modulating H2B Monoubiuitylation.
Molecular Cell (2012), Vol. 46, No. 5, PP. 662-73
Gilad Fuchs, Efrat Shema, Rita Vesterman, Eran Kotler, Zohar Wolchinsky, Sylvia Wilder,
Lior Golomb, Ariel Pribluda, Feng Zhang, Mahmood Haj-Yahya, Ester Feldmesser,
Ashraf Brik, Xiaochun Yu, Jacob Hanna, Daniel Aberdam, Eytan Domany,
Moshe Oren* (Jun, 2012)
DOI: 10.1016/j.molcel.2012.05.023
PubMed
RAP80 is important for genomic stability and is required for stabilizing the BRCA1-A complex at DNA damage sites in vivo.
The Journal of Biological Chemistry (2012), Vol. 287, No. 27, PP. 22919-26
Jiaxue Wu‡, Chao Liu‡, Junjie Chen, Xiaochun Yu (Jun, 2012)
DOI: 10.1074/jbc.M112.351007
PubMed
Chfr and RNF8 synergistically regulate ATM activation.
Nature Structural and Molecular Biology (2011), Vol. 18, No. 7, PP. 761-8
Jiaxue Wu, Yibin Chen, Lin-Yu Lu, Yipin Wu, Michelle T Paulsen, Mats Ljungman,
David O Ferguson, Xiaochun Yu* (Jun, 2011)
DOI: 10.1038/nsmb.2078
PubMed
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis.
Acta Biochimica Biophysica Sinica (Shanghai) (2011), Vol. 43, No. 5, PP. 339-45
Teng Ma‡, Jennifer A Keller‡, Xiaochun Yu* (May, 2011)
DOI: 10.1093/abbs/gmr016
PubMed
WAC, a partner of RNF20/40 complex, regulates histone H2B ubiquitination and gene transcription.
Molecular Cell (2011), Vol. 41, No. 4, PP. 384-97
Feng Zhang, Xiaochun Yu* (Feb, 2011)
DOI: 10.1016/j.molcel.2011.01.024
PubMed
RBX1 RING box protein 1 E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins.
The Journal of Biological Chemistry (2011), Vol. 286, No. 5, PP. 3379-86
Lijun Jia*, Jeremy S Bickel, Jiaxue Wu, Meredith A Morgan, Hua Li, Jie Yang, Xiaochun Yu,
Raymond C Chan*, Yi Sun* (Feb, 2011)
DOI: 10.1074/jbc.M110.188425
PubMed
The Role of BRCA1 in DNA damage response.
Protein & Cell (2010), Vol. 1, No. 2, PP. 117-2.
Jiaxue Wu, Lin-Yu Lu, Xiaochun Yu* (Feb, 2010)
DOI: 10.1007/s13238-010-0010-5
PubMed
MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.
Molecular and Cellular Biology (2010), Vol. 30, No. 22, PP. 5335-47
Xiangzhi Li, Callie Ann Sprunger Corsa, Patricia W Pan, Lipeng Wu, David Ferguson,
Xiaochun Yu, Jinrong Min, Yali Dou* (Nov, 2010)
DOI: 10.1128/MCB.00350-10
PubMed
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis.
Developmental Cell (2010), Vol. 18, No. 3, PP. 371-84
Lin-Yu Lu, Jiaxue Wu, Lin Ye, Galina B Gavrilina, Thomas L Saunders, Xiaochun Yu*
(Mar, 2010)
DOI: 10.1016/j.devcel.2010.01.010
PubMed
Intergrator3, a partner of SSB1, participates in the DNA damage response.
Journal of Biological Chemistry (2009), Vol. 284, No. 44, PP. 30408-15
Feng Zhang‡, Jiaxue Wu‡, Xiaochun Yu* (Oct, 2009)
DOI: 10.1074/jbc.M109.039404
PubMed
PTIP regulates 53BP1 and SMC1 at the DNA damage sites.
Journal of Biological Chemistry (2009), Vol. 284, No. 27, PP. 18078-84
Jiaxue Wu, Marc J Prindle, Gregory R Dressler*, Xiaochun Yu* (Jul, 2009)
DOI: 10.1074/jbc.M109.002527
PubMed
RAD18 transmits DNA damage signaling to elicit homologous recombination repair.
Nature Cell Biology (2009), Vol. 11, No. 5, PP. 592-603
Jun Huang, Michael S Y Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover,
Xiaochun Yu, Junjie Chen* (May, 2009)
DOI: 10.1038/ncb1865
PubMed
PALB2 links BRCA1 and BRCA2 in the DNA damage response.
Current Biology (2009), Vol. 19, No. 6, PP. 524-9
Feng Zhang‡, Jianglin Ma‡, Jiaxue Wu‡, Lin Ye, Hong Cai, Bing Xia*, Xiaochun Yu*
(Mar, 2009)
DOI: 10.1016/j.cub.2009.02.018
PubMed
The balance of Polo-like kinase 1 in tumorigenesis.
Cell Division (2009), Vol. 4, PP. 4
Lin-Yu Lu, Xiaochun Yu* (Jan, 2009)
DOI: 10.1186/1747-1028-4-4
PubMed
Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response.
Molecular and Cellular Biology (2009), Vol. 29, No. 3, PP. 849-60
Jiaxue Wu, Michael S Y Huen, Lin-Yu Lu, Lin Ye, Yali Dou, Mats Ljungman, Junjie Chen,
Xiaochun Yu* (Feb, 2009)
DOI: 10.1128/MCB.01302-08
PubMed
Aurora A is Essential for Early Embryonic Development and Tumor Suppression.
Journal of Biological Chemistry (2008), Vol. 283, No. 46, PP. 31785-90
Lin-Yu Lu‡, Jamie L Wood‡, Lin Ye, Katherine Minter-Dykhouse, Thomas L Saunders,
Xiaochun Yu*, Junjie Chen* (Nov, 2008)
DOI: 10.1074/jbc.M805880200
PubMed
Polo-like Kinase 1 is Essential for Early Embryonic Development and Tumor Suppression.
Molecular and Cellular Biology (2008), Vol. 28, No. 22, PP. 6870-76
Lin-Yu Lu‡, Jamie L Wood‡, Katherine Minter-Dykhouse, Lin Ye, Thomas L Saunders,
Xiaochun Yu*, Junjie Chen* (Nov, 2008)
DOI: 10.1128/MCB.00392-08
PubMed
Loss of Chfr in Human Mammary Epithelial Cells Causes Genomic Instability by Disrupting theMitotic Spindle Assembly Checkpoint.
Neoplasia (2008), Vol. 10, No. 7, PP. 643-52
Lisa M Privette, Jingly Fung Weier, Ha Nam Nguyen, Xiaochun Yu, Elizabeth M Petty*
(Jul, 2008)
DOI: 10.1593/neo.08176
PubMed
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
Cell (2007), Vol. 131, No. 5, PP. 901-14
Michael S Y Huen‡, Robert Grant‡, Isaac Manke, Kay Minn, Xiaochun Yu*, Michael B Yaffe*,
Junjie Chen* (Nov, 2007)
DOI: 10.1016/j.cell.2007.09.041
PubMed
CCDC98 targets BRCA1 to DNA damage sites.
Nature Structural and Molecular Biology (2007), Vol. 14, No. 8, PP. 716-20
Zixing Liu, Jiaxue Wu, Xiaochun Yu* (Aug, 2007)
DOI: 10.1038/nsmb1279
PubMed
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage responses.
Science (2007), Vol. 316, No. 5828, PP. 1202-5
Hongtae Kim, Junjie Chen*, Xiaochun Yu* (May, 2007)
DOI: 10.1126/science.1139621
PubMed
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.
Genes & Development (2006), Vol. 20, No. 13, PP. 1721-26
Xiaochun Yu‡, Shuang Fu‡, Maoyi Lai, Richard Baer*, Junjie Chen* (Jul, 2006)
DOI: 10.1101/gad.1431006
PubMed
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice
Molecular and Cellular Biology (2005), Vol. 25, No. 22, PP. 10079-86
Irene M Ward, Simone Difilippantonio, Kay Minn, Melissa D Mueller, Julian R Molina,
Xiaochun Yu, Craig S Frisk, Thomas Ried, Andre Nussenzweig, Junjie Chen* (Nov, 2005)
DOI: 10.1128/MCB.25.22.10079-10086.2005
PubMed
Chfr is required for tumor suppression and Aurora A regulation.
Nature Genetics (2005), Vol. 37, No. 4, PP. 401-6
Xiaochun Yu, Katherine Minter-Dykhouse, Liviu Malureanu, Wei-Meng Zhao, Dongwei Zhang,
Carolin J Merkle, Irene M Ward, Hideyuki Saya, Guowei Fang, Jan van Deursen,
Junjie Chen* (Apr, 2005)
DOI: 10.1038/ng1538
PubMed
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 BRCT domains.
Molecular and Cellular Biology (2004), Vol. 24, No. 21, PP. 9478-86
Xiaochun Yu, Junjie Chen* (Nov, 2004)
DOI: 10.1128/MCB.24.21.9478-9486.2004
PubMed
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.
Structure (London, England) (2004), Vol. 12, No. 7, PP. 1137-46
Maria Victoria E Botuyan‡, Yves Nominé‡, Xiaochun Yu‡, Nenad Juranic, Slobodan Macura,
Junjie Chen*, Georges Mer* (Jul, 2004)
DOI: 10.1016/j.str.2004.06.002
PubMed
Phosphopeptide binding specificities of BRCT domains.
Journal of Biological Chemistry (2003), Vol. 278, No. 52, PP. 52914-8
Maria Rodriguez‡, Xiaochun Yu‡, Junjie Chen, Zhou Songyang* (Dec, 2003)
DOI: 10.1074/jbc.C300407200
PubMed
The BRCT domain is a phospho-protein binding domain.
Science (2003), Vol. 304, No. 5645, PP. 639-42
Xiaochun Yu, Claudia Christiano Silva Chini, Miao He, Georges Mer, Junjie Chen*
(Oct, 2003)
DOI: 10.1126/science.1088753
PubMed
Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling
Molecular Biology of the Cell (2002), Vol. 13, No. 7, PP. 2547-57
Xiaochun Yu‡, Kailash D Sharma‡, Tsuyoshi Takahashi, Ryo Iwamoto, Eisuke Mekada*
(Jul, 2002)
DOI: 10.1091/mbc.01-08-0411
PubMed
Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites
Journal of Cell Science (2000), Vol. 113, No. 12, PP. 2139-47
Xiaochun Yu, Shingo Miyamoto, Eisuke Mekada* (Jun, 2000)
DOI: 10.1242/jcs.113.12.2139
PubMed
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