Poly-ADP ribosylation in DNA damage response and cancer therapy.
Mutation Research (2019), Vol. 780, PP. 82-91
Wei-Hsien Hou, Shih-Hsun Chen, Xiaochun Yu* (Apr, 2019)
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Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.
Science Advances (2019), Vol. 5, No. 4, PP. eaav4340
Shih-Hsun Chen, Xiaochun Yu* (Apr, 2019)
DOI: 10.1126/sciadv.aav4340
The role of dePARylation in DNA damage repair and cancer suppression.
DNA repair (2019), Vol. 76, PP. 20-29
Muzaffer Ahmad Kassab, Xiaochun Yu* (Apr, 2019)
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NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.
Nature Communications (2019), Vol. 10, No. 1, PP. 693
Chunjing Bian‡, Chao Zhang‡, Tao Luo‡, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong, Xiaochun Yu* (Feb, 2019)
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Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation.
Nucleic Acids Research (2019), Vol. 47, No. 3, PP. 1321-1334
Shih-Hsun Chen, Xiaochun Yu* (Feb, 2019)
SIRT1 activation disrupts maintenance of myelodysplastic syndrome stem and progenitor cells by restoring TET2 function.
Cell Stem Cell (2018), Vol. 23, No. 3, PP. 355-69
Jie Sun, Xin He, Yinghui Zhu, Zonghui Ding, Haojie Dong, Yimei Feng, Juan Du, Hanying Wang,
Xiwei Wu, Lei Zhang, Xiaochun Yu, Allen Lin, Tinisha McDonald, Dandan Zhao, Herman Wu,
Wei-Kai Hua, Bin Zhang, Lifeng Feng, Kaoru Tohyama, Ravi Bhatia, Philipp Oberdoerffer,
Yang Jo Chung, Peter D Aplan, Jacqueline Boultwood, Andrea Pellagatti, Samer Khaled,
Marcin Kortylewski, Flavia Pichiorri, Ya-Huei Kuo, Nadia Carlesso, Guido Marcucci,
Hongchuan Jin*, Ling Li* (Sep, 2018)
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PARP2 mediates branched poly-ADP-ribosylation in response to DNA damage.
Nature Communications (2018), Vol. 9, No. 1, PP. 3233
Qian Chen, Muzaffer Ahmad Kassab, Françoise Dantzer, Xiaochun Yu* (Aug, 2018)
DOI: 10.1038/s41467-018-05588-5
LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway.
Oncogenesis (2018), Vol. 7, No. 8, PP. 57
Xiangfei Wang, Xiumin Wang, Yang Liu, Yating Dong, Yanan Wang, Muzaffer Ahmad Kassab,
Wufang Fan*, Xiaochun Yu*, Chen Wu* (Aug, 2018)
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Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation.
The Journal of Biological Chemistry (2018), Vol. 293, No. 37, PP. 14470-80
Mengxi Wang‡, Zenglin Yuan‡, Rong Xie‡, Yinliang Ma, Xiuhua Liu*, Xiaochun Yu*
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Structure basis for the inhibition of the methyl-lysine binding function of 53BP1 by NUDT16L1/TIRR.
Nature Communications (2018), Vol. 9, No. 1, PP. 2689
Jiaxu Wang‡, Zenglin Yuan‡, Yaqi Cui‡, Rong Xie, Guang Yang, Muzaffer A Kassab,
Mengxi Wang, Yinliang Ma, Chen Wu, Xiaochun Yu*, Xiuhua Liu* (Jul, 2018)
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GALNT14 involves the regulation of multidrug resistance in breast cancer.
Translational Oncology (2018), Vol. 11, No. 3, PP. 786-93
Jinshuai Shan, Yang Liu, Yukun Wang, Yimiao Li, Xiaochun Yu*, Chen Wu* (Jun, 2018)
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Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors.
Nucleic Acids Research (2018), Vol. 46, No. 7, PP. 3446-57
Guang Yang, Chao Liu, Shih-Hsun Chen, Muzaffer A Kassab, J Damon Hoff, Nils G Walter,
Xiaochun Yu* (Apr, 2018)
EFEMP2 Mediates GALNT14-Dependent Breast Cancer Cell Invasion.
Translational Oncology (2018), Vol. 11, No. 2, PP. 346-52
Tao Zuo‡, Jinshuai Shan‡, Yang Liu, Rong Xie, Xiaochun Yu*, Chen Wu* (Apr, 2018)
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The role of poly ADP-ribosylation in the first wave of DNA damage response.
Nucleic Acids Research (2017), Vol. 45, No. 14, PP. 8129-41
Chao Liu, Aditi Vyas, Muzaffer A. Kassab, Anup K. Singh, Xiaochun Yu* (Aug, 2017)
Targeting reactive nitrogen species suppresses hereditary pancreatic cancer
Proceedings of the National Academy of Sciences (2017), Vol. 114, No. 27, PP. 7106-11
Mo Li, Qian Chen, Teng Ma, Xiaochun Yu* (Jul, 2017)
DOI: 10.1073/pnas.1702156114
UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.
Epigenetics (2017), Vol. 12, No. 7, PP. 551-60
Yidan Liu, Bin Zhang, Xiaoyu Meng, Matthew J Korn, Jack M Parent, Lin-Yu Lu*,
Xiaochun Yu* (Jul, 2017)
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CTCF participates in DNA damage response via poly(ADP-ribosyl)ation.
Science Reports (2017), Vol. 7, PP. 43530
Deqiang Han‡, Qian Chen‡, Jiazhong Shi‡, Feng Zhang, Xiaochun Yu* (Mar, 2017)
Chemopreventive effects of ROS targeting in a murine model of BRCA1-deficient breast cancer.
Cancer Research (2017), Vol. 77, No. 2, PP. 448-58
Mo Li, Qian Chen, Xiaochun Yu* (Jan, 2017)
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OGT restrains the expansion of DNA damage signaling.
Nucleic Acids Research (2016), Vol. 44, No. 19, PP. 9266-78
Qiang Chen, Xiaochun Yu* (Nov, 2016)
A special Issue on DNA damage response and genomic instability.
Acta Biochimica et Biophysica Sinica (Shanghai) (2016), Vol. 48, No. 7, PP. 593
Xiaochun Yu* (Jul, 2016)
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Functions of PARylation in DNA damage repair pathway.
Genomics Proteomics Bioinformatics (2016), Vol. 14, No. 3, PP. 131-9
Huiting Wei, Xiaochun Yu* (Jun, 2016)
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Zinc Finger Protein 618 regulates the function of UHRF2 as a specific 5-hydroxymenthylcytosine reader.
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Yidan Liu, Bin Zhang, Henry Kuang, Gautam Korakavi, Lin-Yu Lu*, Xiaochun Yu*
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Patient-Level DNA Damage and Repair Pathway Profiles and Prognosis After Prostatectomy for High-Risk Prostate Cancer.
JAMA Oncology (2016), Vol. 2, No. 4, PP. 471-80
Joseph R Evans, Shuang G Zhao, S Laura Chang, Scott A Tomlins, Nicholas Erho,
Andrea Sboner, Matthew J Schiewer, Daniel E Spratt, Vishal Kothari, Eric A Klein,
Robert B Den, Adam P Dicker, R Jeffrey Karnes, Xiaochun Yu, Paul L Nguyen,
Mark A Rubin, Johann de Bono, Karen E Knudsen, Elai Davicioni, Felix Y Feng*
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CHFR is important for the survival of male premeiotic germ cells.
Cell Cycle (2015), Vol. 14, No. 21, PP. 3454-60
Lin-Yu Lu, Xiaochun Yu* (Nov, 2015)
DOI: 10.1080/15384101.2015.1093701
Poly(ADP-ribosyl)ation mediates the BRCA2-dependent early DNA damage response.
Cell Reports (2015), Vol. 13, No. 4, PP. 678-89
Feng Zhang, Jiazhong Shi, Chunjing Bian, Xiaochun Yu* (Oct, 2015)
DOI: 10.1016/j.celrep.2015.09.040
The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response.
Nucleic Acids Research (2015), Vol. 43, No. 22, PP. 10782-94
Feng Zhang‡, Jiazhong Shi‡, Shih-Hsun Chen, Chunjing Bian, Xiaochun Yu* (Dec, 2015)
ATDC (Ataxia Telangiectasia Group D Complementing) Promotes Radioresistance through an Interaction with the RNF8 Ubiquitin Ligase.
The Journal of Biological Chemistry (2015), Vol. 290, No. 45, PP. 27146-57
Huibin Yang‡, Phillip L Palmbos‡, Lidong Wang, Evelyn H Kim, Gina M Ney,
Chao Liu, Jayendra Prasad, David E Misek, Xiaochun Yu, Mats Ljungman,
Diane M Simeone* (Nov, 2015)
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RNF8 deficiency results in neurodegeneration in mice.
Neurobiology of Aging (2015), Vol. 36, No. 10, PP. 2850-60
Siwei Ouyang‡, Yanfeng Song‡, Yingxia Tian‡, Yibin Chen, Xiaochun Yu,
Degui Wang* (Oct, 2015)
DOI: 10.1016/j.neurobiolaging.2015.07.010
ADP-ribosyltransferases and Poly ADP-ribosylation.
Current Protein and Peptide Scicnce (2015), Vol. 16, No. 6, PP. 491-501
Chao Liu, Xiaochun Yu* (May, 2015)
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Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.
Molecular Cell (2015), Vol. 58, No. 1, PP. 172-85
Wenxia Jiang‡, Jennifer L Crowe‡, Xiangyu Liu‡, Satoshi Nakajima, Yunyue Wang,
Chen Li, Brian J Lee, Richard L Dubois, Chao Liu, Xiaochun Yu, Li Lan, Shan Zha*
(Apr, 2015)
DOI: 10.1016/j.molcel.2015.02.024
ZNF644 and WIZ regulate the G9a/GLP complex for gene repression.
eLife (2015), Vol. 4, PP. e05606
Chunjing Bian‡, Qiang Chen‡, Xiaochun Yu* (Mar, 2015)
Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage.
BMB Reports (2015), Vol. 48, No. 6, PP. 354-9
Chao Zhang, Tao Luo, Shijun Cui, Yongquan Gu, Chunjing Bian, Yibin Chen, Xiaochun Yu*,
Zhonggao Wang* (Jun, 2015)
DOI: 10.5483/BMBRep.2015.48.6.012
Double-strand break repair on sex chromosomes: challenges during male meiotic prophase.
Cell Cycle (2015), Vol. 14, No. 4, PP. 516-25
Lin-Yu Lu*, Xiaochun Yu* (Jan, 2015)
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Topoisomerase II regulates the maintenance of DNA Methylation.
The Journal of Biological Chemistry (2015), Vol. 290, No. 2, PP. 851-60
Lin-Yu Lu*, Henry Kuang, Gautam Korakavi, Xiaochun Yu* (Jan, 2015)
DOI: 10.1074/jbc.M114.611509
The role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapy.
Oncogene (2015), Vol. 34, No. 26, PP. 3349-56
Mo Li, Xiaochun Yu* (Jun, 2015)
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